Protein Details: Glutamate receptor ionotropic; NMDA 2C
Protein ID
ICDB_Pro_0732
Protein Name
Glutamate receptor ionotropic; NMDA 2C
Gene Name
Grin2c
Organism
Rattus norvegicus (Rat)
Length
1237 amino acids
AlphaFoldDB
AF-Q00961-F1-model_v4.pdb
Function
Component of NMDA receptor complexes that function as heterotetrameric; ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit; glycine binding to the zeta subunit; plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current; long-term synaptic potentiation; and learning (By similarity).
Sequence
Ligand Binding
Binding Site
BINDING 509..511; /ligand="L-glutamate"; BINDING 511; /ligand="L-glutamate"; BINDING 516; /ligand="L-glutamate"; BINDING 687..688; /ligand="L-glutamate"; BINDING 729; /ligand="L-glutamate"
Disease
Location
Detected in cerebellum
DOI ID
10.1126/science.256.5060.1217; 10.1016/s0021-9258(18)53849-7; 10.1126/science.7569905; 10.1006/mcne.1998.0679; 10.1038/ncomms1871; 10.1124/mol.116.106781
RefSeq
NP_036707.3; XP_006247769.1; XP_006247771.1; XP_017452475.1; XP_017452476.1; XP_017452477.1; XP_017452478.1; XP_017452479.1; XP_017452480.1; XP_017452481.1